H Terence Cook Selected Research

Complement Factor H Deficiency

1/2021	Complement activity is regulated in C3 glomerulopathy by IgG-factor H fusion proteins with and without properdin targeting domains.
11/2013	A rare case: childhood-onset C3 glomerulonephritis due to homozygous factor H deficiency.
8/2010	Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice.
2/2008	Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice.

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H Terence Cook Research Topics

Disease

58	Glomerulonephritis 01/2022 - 11/2001
20	Inflammation (Inflammations) 01/2022 - 12/2002
18	Nephritis 05/2015 - 11/2001
17	IGA Glomerulonephritis (IGA Nephropathy) 12/2023 - 05/2009
16	Proteinuria 12/2023 - 11/2001
12	Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II) 01/2022 - 08/2002
10	Lupus Nephritis 04/2022 - 05/2005
9	Vasculitis (Vasculitides) 01/2022 - 11/2004
8	Kidney Diseases (Kidney Disease) 01/2022 - 05/2013
8	Systemic Lupus Erythematosus (Libman-Sacks Disease) 02/2016 - 01/2003
7	Renal Insufficiency (Renal Failure) 11/2021 - 05/2005
6	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 10/2021 - 11/2004
6	Atypical Hemolytic Uremic Syndrome 01/2020 - 08/2010
6	Necrosis 11/2017 - 11/2001
6	Albuminuria 01/2013 - 02/2002
5	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 02/2004
5	Chronic Kidney Failure (Chronic Renal Failure) 04/2017 - 01/2007
4	Complement Factor H Deficiency 01/2021 - 02/2008
4	Fibrosis (Cirrhosis) 03/2016 - 10/2002
4	Anti-Glomerular Basement Membrane Disease (Goodpasture's Syndrome) 06/2015 - 07/2011
4	Hemorrhage 10/2014 - 11/2004
4	Genetic Predisposition to Disease (Genetic Predisposition) 02/2012 - 02/2007
3	Membranous Glomerulonephritis (Membranous Nephropathy) 10/2021 - 07/2015
3	Infections 10/2021 - 07/2011
3	Lipoid Nephrosis (Glomerulonephritis, Minimal Change) 10/2021 - 07/2015
3	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 10/2021 - 09/2006
3	Systemic Vasculitis 01/2020 - 01/2006
3	Hematuria 11/2019 - 04/2009
3	Thrombotic Microangiopathies 01/2019 - 01/2011
3	Cicatrix (Scar) 01/2014 - 10/2002
2	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2020 - 05/2017
2	Hereditary Nephritis (Alport Syndrome) 03/2016 - 11/2006
2	Acute Kidney Injury (Acute Renal Failure) 02/2015 - 06/2005
2	Sclerosis 01/2014 - 03/2011
2	Hemolytic-Uremic Syndrome 05/2013 - 06/2007
2	Thrombosis (Thrombus) 01/2013 - 02/2004
2	Disease Susceptibility (Diathesis) 01/2012 - 02/2004
2	Reperfusion Injury 01/2008 - 09/2004
1	Diarrhea 12/2023
1	Hypertension (High Blood Pressure) 12/2023
1	Lung Injury 10/2021

Drug/Important Bio-Agent (IBA)

28	Complement System Proteins (Complement)IBA 01/2022 - 09/2004
15	Proteins (Proteins, Gene)FDA Link 12/2023 - 05/2005
14	Antigen-Antibody Complex (Immune Complex)IBA 01/2022 - 01/2003
14	Complement Factor H (Factor H)IBA 01/2021 - 08/2002
14	AntibodiesIBA 01/2021 - 02/2002
12	CreatinineIBA 12/2023 - 01/2003
12	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 10/2021 - 09/2005
8	CytokinesIBA 12/2023 - 04/2003
7	Immunoglobulin G (IgG)IBA 08/2011 - 12/2002
6	Immunoglobulin A (IgA)IBA 12/2023 - 05/2009
6	Complement C3 (C3 Complement)IBA 01/2022 - 04/2014
6	AutoantibodiesIBA 01/2022 - 12/2004
6	Dichlorodiphenyldichloroethane (DDD)IBA 01/2019 - 09/2007
6	Collagen Type IV (Type IV Collagen)IBA 03/2016 - 05/2005
5	Syk KinaseIBA 12/2023 - 02/2010
5	Peroxidase (Myeloperoxidase)IBA 10/2021 - 09/2005
5	Monoclonal AntibodiesIBA 01/2020 - 02/2002
4	fostamatinibIBA 12/2023 - 02/2010
4	Immunoglobulins (Immunoglobulin)IBA 01/2022 - 09/2005
4	SteroidsIBA 01/2020 - 10/2011
4	Urea (Carbamide)FDA LinkGeneric 03/2016 - 04/2012
4	AntigensIBA 05/2015 - 11/2004
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2010 - 05/2005
3	Biomarkers (Surrogate Marker)IBA 04/2022 - 01/2017
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2020 - 09/2015
3	Mycophenolic Acid (Cellcept)FDA LinkGeneric 01/2019 - 08/2013
3	AutoantigensIBA 05/2015 - 07/2011
3	Rituximab (Mabthera)FDA Link 08/2013 - 09/2007
3	Purinergic P2X7 ReceptorsIBA 01/2013 - 02/2007
3	antiglomerular basement membrane antibodyIBA 05/2012 - 02/2002
3	Transcription Factors (Transcription Factor)IBA 07/2011 - 01/2008
3	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 02/2010 - 11/2004
2	HLA Antigens (Human Leukocyte Antigens)IBA 01/2021 - 07/2011
2	Tacrolimus (Prograf)FDA LinkGeneric 01/2020 - 01/2019
2	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 01/2019 - 09/2004
2	LipidsIBA 01/2019 - 08/2009
2	Immunoglobulin M (IgM)IBA 05/2017 - 02/2008
2	Pertussis ToxinIBA 09/2015 - 04/2009
2	Lipoproteins (Lipoprotein)IBA 09/2015 - 08/2009
2	Protein Isoforms (Isoforms)IBA 09/2015 - 04/2003
2	Leukocyte L1 Antigen Complex (Calgranulin)IBA 05/2015 - 06/2013
2	Fc Receptors (Fc Receptor)IBA 02/2012 - 05/2010
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 07/2011 - 05/2008
2	Complement C5 (Complement 5)IBA 05/2011 - 01/2011
2	Indicators and Reagents (Reagents)IBA 03/2011 - 01/2010
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 07/2010 - 02/2002
2	AlbuminsIBA 08/2009 - 09/2003
2	Messenger RNA (mRNA)IBA 06/2009 - 02/2007
2	GlobulinsIBA 06/2007 - 09/2003
2	CollagenIBA 11/2006 - 03/2006
2	ChemokinesIBA 09/2005 - 11/2004
2	IntegrinsIBA 01/2003 - 10/2002
1	EnzymesIBA 12/2023
1	danicopanIBA 01/2022
1	InflammasomesIBA 01/2022

Therapy/Procedure

15	Therapeutics 10/2021 - 02/2002
2	Aftercare (After-Treatment) 01/2019 - 01/2017
2	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2012 - 12/2004
2	Treatment Delay 01/2003 - 10/2002